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Marina Kreutz Selected Research

Diclofenac (SR 38)

10/2019Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.
1/2019Metabolic targeting synergizes with MAPK inhibition and delays drug resistance in melanoma.
1/2019Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis.
8/2018Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma.
1/2018Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells.
1/2015Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms.
2/2013Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model.
1/2013New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.

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Marina Kreutz Research Topics

Disease

39Neoplasms (Cancer)
05/2022 - 01/2003
7Melanoma (Melanoma, Malignant)
01/2019 - 03/2006
6Glioma (Gliomas)
08/2018 - 08/2009
5Graft vs Host Disease (Graft-Versus-Host Disease)
01/2021 - 01/2012
4Glioblastoma (Glioblastoma Multiforme)
08/2018 - 01/2013
4Carcinoma (Carcinomatosis)
09/2014 - 03/2006
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2020 - 01/2018
3Lactic Acidosis
01/2020 - 08/2012
3Infections
01/2019 - 12/2006
3Hypoxia (Hypoxemia)
10/2018 - 04/2009
2Leukemia
10/2020 - 01/2013
2Renal Cell Carcinoma (Grawitz Tumor)
09/2018 - 05/2011
2Brain Neoplasms (Brain Tumor)
08/2018 - 01/2016
1Colitis
12/2021
1Head and Neck Neoplasms (Head and Neck Cancer)
12/2021
1COVID-19
11/2021
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2019
1Hematologic Neoplasms (Hematological Malignancy)
01/2019
1Actinic Keratosis
01/2019
1Hodgkin Disease (Hodgkin's Disease)
09/2018
1Urinary Bladder Neoplasms (Bladder Cancer)
09/2018
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
09/2018
1Neoplasm Metastasis (Metastasis)
01/2017
1Wounds and Injuries (Trauma)
01/2017
1Squamous Cell Carcinoma of Head and Neck
09/2014
1Acidosis
08/2012

Drug/Important Bio-Agent (IBA)

22Lactic Acid (Lactate)FDA LinkGeneric
05/2022 - 03/2006
11Glucose (Dextrose)FDA LinkGeneric
07/2021 - 04/2009
8Diclofenac (SR 38)FDA LinkGeneric
10/2019 - 01/2013
7Lactate Dehydrogenase 5IBA
01/2021 - 08/2009
5L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
07/2021 - 08/2009
5Proteins (Proteins, Gene)FDA Link
09/2014 - 01/2003
5CytokinesIBA
08/2012 - 03/2006
4Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
10/2019 - 01/2015
4Pharmaceutical PreparationsIBA
10/2019 - 01/2013
3Protons (Proton)IBA
05/2022 - 01/2017
3AntigensIBA
12/2021 - 03/2006
3Pyruvic Acid (Pyruvate)IBA
07/2021 - 08/2009
3Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
04/2021 - 01/2018
3Messenger RNA (mRNA)IBA
01/2021 - 12/2003
3Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
01/2021 - 04/2009
3Oxygen (Dioxygen)IBA
10/2018 - 05/2011
3Metformin (Glucophage)FDA LinkGeneric
08/2018 - 01/2016
3Interleukin-6 (Interleukin 6)IBA
02/2008 - 05/2003
2KynurenineIBA
12/2021 - 12/2011
2Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA
12/2021 - 03/2011
2alpha-hydroxyglutarateIBA
04/2021 - 01/2018
2Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA
01/2021 - 12/2016
2EnzymesIBA
10/2018 - 08/2009
2Amino AcidsFDA Link
01/2017 - 08/2012
2Transforming Growth Factors (Transforming Growth Factor)IBA
01/2016 - 01/2013
2Peptides (Polypeptides)IBA
10/2013 - 01/2013
2Toll-Like Receptors (Toll-Like Receptor)IBA
02/2013 - 01/2003
2Interleukin-10 (Interleukin 10)IBA
02/2013 - 02/2008
2Transforming Growth Factor beta2IBA
01/2013 - 08/2009
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2012 - 02/2009
2Transcription Factors (Transcription Factor)IBA
08/2009 - 04/2009
2Macrophage Colony-Stimulating FactorIBA
02/2008 - 03/2006
2Conditioned Culture MediaIBA
03/2006 - 05/2003
1Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
12/2021
1Basigin (Extracellular Matrix Metalloproteinase Inducer (EMMPRIN))IBA
11/2021
1Dexamethasone (Maxidex)FDA LinkGeneric
11/2021
1GlycosphingolipidsIBA
07/2021
1Heat-Shock Proteins (Heat-Shock Protein)IBA
07/2021
1GNE-140IBA
07/2021
1Sodium Bicarbonate (Baking Soda)FDA LinkGeneric
10/2020
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
10/2019
1Oxidoreductases (Dehydrogenase)IBA
02/2019
1lumiracoxib (prexige)IBA
01/2019
1VemurafenibIBA
01/2019
1Antimicrobial PeptidesIBA
01/2019
1CarbonIBA
01/2019
1Cholecalciferol (Vitamin D3)FDA Link
01/2019
1VitaminsIBA
01/2019
1DefensinsIBA
01/2019
1Cytostatic AgentsIBA
01/2019
1Lactate DehydrogenasesIBA
10/2018
1Monoclonal AntibodiesIBA
09/2018
1Diflunisal (Dolobid)FDA Link
01/2018
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2017
1Waste Products (Waste Product)IBA
01/2017
1Ibuprofen (Motrin)FDA LinkGeneric
01/2015
1Anti-Bacterial Agents (Antibiotics)IBA
05/2014
1Interleukin-12 (IL 12)IBA
02/2013
1Transforming Growth Factor beta (TGF-beta)IBA
01/2013
1ChemokinesIBA
08/2012
1LipidsIBA
08/2012
1Adenosine (Adenocard)FDA LinkGeneric
08/2012
1NucleotidesIBA
08/2012
1Quinolinic AcidIBA
12/2011
1CreatinineIBA
12/2011

Therapy/Procedure

10Therapeutics
05/2022 - 08/2012
6Immunotherapy
01/2022 - 03/2011
3Cell Transplantation
10/2020 - 01/2012
2Hematopoietic Stem Cell Transplantation
01/2019 - 12/2016
1Aftercare (After-Treatment)
01/2019
1Drug Therapy (Chemotherapy)
09/2018
1Antibiotic Prophylaxis
05/2014
1Transplantation
05/2014
1Stem Cell Transplantation
05/2014